A novel method for Magnetic Resonance Spectroscopy lipid signal suppression using Semi-classical signal analysis and Bidirectional Long short-term memory

Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul:2022:317-320. doi: 10.1109/EMBC48229.2022.9871645.

Abstract

Magnetic resonance spectroscopy (MRS) is a non-invasive method that enables the analysis and quantification of brain metabolites, which provide useful information about the neuro-biological substrates of brain function. Lactate plays a pivotal role in the diagnosis of various brain diseases. However, accurate lactate quantification is generally difficult to achieve due to the presence of large lipid peaks resonating at a similar spectral position. To overcome this problem several techniques have been proposed. However, most of them suffer from lactate signal loss or poor lipid peak removal. In this paper, a novel method for lipid suppression for MRS signal is proposed. The method combines a semi-classical signal analysis method and a bidirectional long short term memory technique. The method is validated using simulated data that mimics real MRS data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Lactic Acid
  • Lipids
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy / methods
  • Memory, Short-Term*

Substances

  • Lipids
  • Lactic Acid