Novel biodegradable two-dimensional vanadene augmented photoelectro-fenton process for cancer catalytic therapy

Yichu Nie; Weilang Zhang; Wenqing Xiao; Weiwei Zeng; Ting Chen; Weiqiang Huang; Xixi Wu; Yong Kang; Jinrui Dong; Wei Luo; Xiaoyuan Ji

doi:10.1016/j.biomaterials.2022.121791

Novel biodegradable two-dimensional vanadene augmented photoelectro-fenton process for cancer catalytic therapy

Biomaterials. 2022 Oct:289:121791. doi: 10.1016/j.biomaterials.2022.121791. Epub 2022 Sep 3.

Authors

Yichu Nie¹, Weilang Zhang², Wenqing Xiao², Weiwei Zeng³, Ting Chen², Weiqiang Huang⁴, Xixi Wu⁴, Yong Kang⁵, Jinrui Dong⁵, Wei Luo⁶, Xiaoyuan Ji⁷

Affiliations

¹ Clinical Research Institute, First People's Hospital of Foshan, Foshan, 528000, China.
² Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.
³ Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China. Electronic address: zengww7@mail2.sysu.edu.cn.
⁴ Department of Radiation Oncology, Nanfang Hospital Southern Medical University, Guangzhou, 510515, China.
⁵ Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China.
⁶ Clinical Research Institute, First People's Hospital of Foshan, Foshan, 528000, China. Electronic address: luowei_421@163.com.
⁷ Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China. Electronic address: jixiaoyuan@tju.edu.cn.

PMID: 36084481
DOI: 10.1016/j.biomaterials.2022.121791

Abstract

Fenton reaction-based chemodynamic therapy is hardly a self-sufficient cancer treatment, due to its stringent reaction conditions, limited substrate concentration, and negative feedback from the tumor microenvironment. Herein, we synthesized a novel two-dimensional (2D) vanadium-based nanosheets (Vanadene, V NSs) with polyvalent surfaces (V^IV/V^V), a very narrow band gap of 0.8 eV, and high biodegradability by a liquid-phase exfoliation strategy. The polyvalent surface endowed its multiple capabilities to modulate TME through GSH consumption and O₂ production via V^V and to catalyze a Fenton-like reaction to produce ·OH under a mild condition via V^IV. In addition, efficient energy conversions including near-infrared (NIR)-thermal conversion (photothermal therapy, PTT) and NIR-electron conversion (photodynamic therapy, PDT) were ensured by the narrow band gap, in which NIR-thermal conversion enhanced the Fenton-like reaction activity through accelerating ionization while NIR-electron conversion catalyzed the conversion of O₂ to ·O₂^- for further breaking redox homeostasis. Moreover, V NSs-based nanocatalyst can be slowly degraded into non-toxic species, enabling it to be innocuously eliminated from the body after completing tumor eradication by single drug injection and single NIR irradiation. Therefore, this study provides new insights into a universal nanoplatform for NIR-enhanced combination cancer therapy, highlighting the utility of 2D V NSs in the field of biomedicine.

Keywords: Chemodynamic therapy; Fenton reaction; Photodynamic therapy; Two-dimensional nanomaterials; Vanadene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cell Line, Tumor
Humans
Hydrogen Peroxide
Nanoparticles* / therapeutic use
Neoplasms* / drug therapy
Photochemotherapy* / methods
Phototherapy / methods
Tumor Microenvironment
Vanadium

Substances

Vanadium
Hydrogen Peroxide