Regulation of heme utilization and homeostasis in Candida albicans

PLoS Genet. 2022 Sep 9;18(9):e1010390. doi: 10.1371/journal.pgen.1010390. eCollection 2022 Sep.

Abstract

Heme (iron-protoporphyrin IX) is an essential but potentially toxic cellular cofactor. While most organisms are heme prototrophs, many microorganisms can utilize environmental heme as iron source. The pathogenic yeast Candida albicans can utilize host heme in the iron-poor host environment, using an extracellular cascade of soluble and anchored hemophores, and plasma membrane ferric reductase-like proteins. To gain additional insight into the C. albicans heme uptake pathway, we performed an unbiased genetic selection for mutants resistant to the toxic heme analog Ga3+-protoporphyrin IX at neutral pH, and a secondary screen for inability to utilize heme as iron source. Among the mutants isolated were the genes of the pH-responsive RIM pathway, and a zinc finger transcription factor related to S. cerevisiae HAP1. In the presence of hemin in the medium, C. albicans HAP1 is induced, the Hap1 protein is stabilized and Hap1-GFP localizes to the nucleus. In the hap1 mutant, cytoplasmic heme levels are elevated, while influx of extracellular heme is lower. Gene expression analysis indicated that in the presence of extracellular hemin, Hap1 activates the heme oxygenase HMX1, which breaks down excess cytoplasmic heme, while at the same time it also activates all the known heme uptake genes. These results indicate that Hap1 is a heme-responsive transcription factor that plays a role both in cytoplasmic heme homeostasis and in utilization of extracellular heme. The induction of heme uptake genes by C. albicans Hap1 under iron satiety indicates that preferential utilization of host heme can be a dietary strategy in a heme prototroph.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida albicans / genetics
  • Candida albicans / metabolism
  • Heme Oxygenase (Decyclizing) / chemistry
  • Heme Oxygenase (Decyclizing) / metabolism
  • Heme* / genetics
  • Heme* / metabolism
  • Hemin / metabolism
  • Hemin / pharmacology
  • Homeostasis / genetics
  • Iron / metabolism
  • Peroxidases / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins* / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Heme
  • Hemin
  • Iron
  • HMX1 protein, S cerevisiae
  • Peroxidases
  • Heme Oxygenase (Decyclizing)

Grants and funding

This study was supported by Israel Science Foundation (https://isf.org.il) grant 587/19 to DK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.