On-DNA-1,2,3-Triazole Formation via Click Reaction

Methods Mol Biol. 2022:2541:39-43. doi: 10.1007/978-1-0716-2545-3_6.

Abstract

Copper-catalyzed azide-alkyne cycloaddition (CuAAC) provides a simple and convenient strategy to synthesize diverse 1,2,3-triazoles for drug discovery. Described herein is a protocol for the CuSO4-catalyzed cycloaddition between alkynes and DNA-appended azides.

Keywords: 1,2,3-triazole; Click chemistry; Copper-catalyzed azide-alkyne cycloaddition; CuAAC; DNA-encoded library (DEL).

MeSH terms

  • Alkynes
  • Azides*
  • Catalysis
  • Click Chemistry / methods
  • Copper
  • Cycloaddition Reaction
  • DNA
  • Triazoles*

Substances

  • Alkynes
  • Azides
  • Triazoles
  • Copper
  • DNA