Copper-catalyzed azide-alkyne cycloaddition (CuAAC) provides a simple and convenient strategy to synthesize diverse 1,2,3-triazoles for drug discovery. Described herein is a protocol for the CuSO4-catalyzed cycloaddition between alkynes and DNA-appended azides.
Keywords: 1,2,3-triazole; Click chemistry; Copper-catalyzed azide-alkyne cycloaddition; CuAAC; DNA-encoded library (DEL).
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