Pan-Cancer Analysis Reveals the Relation between TRMT112 and Tumor Microenvironment

Haitao Xu; Caihong Jiang; Fusheng Yao; Hong Liang; Hong Yan; Dangui Chen; Youzhi Wu; Long Zhong

doi:10.1155/2022/1445932

Pan-Cancer Analysis Reveals the Relation between TRMT112 and Tumor Microenvironment

J Oncol. 2022 Aug 30:2022:1445932. doi: 10.1155/2022/1445932. eCollection 2022.

Authors

Haitao Xu¹, Caihong Jiang², Fusheng Yao¹, Hong Liang¹, Hong Yan¹, Dangui Chen¹, Youzhi Wu¹, Long Zhong¹

Affiliations

¹ Department of Hematology, Anqing Municipal Hospital, Anqing Medical Center Affiliated to Anhui Medical University, Anqing, China.
² Department of Pediatric Surgery, Anqing Municipal Hospital, Anqing Medical Center Affiliated to Anhui Medical University, Anqing, China.

Abstract

Dysregulated epigenetic modifications play a critical role in cancer development where TRMT112 is a member of the transfer RNA (tRNA) methyltransferase family. Till now, no studies have revealed the linkage between TRMT112 expression and diverse types of tumors. Based on TCGA data, we first probed into the relation between TRMT112 and prognosis and the potential role of TRMT112 in tumor microenvironment across 33 types of tumor. TRMT112 presented with increased expression in most cancers, which was significantly prognostic. Furthermore, TRMT112 was associated with tumor-associated fibroblasts in a variety of cancers. Additionally, a positive relationship was identified between TRMT112 expression and multiple tumor-related immune infiltrations, such as dendritic cells, CD8+ T cells, macrophages, CD4+ T cells, neutrophils, and B cells in lung adenocarcinoma and breast invasive carcinoma. In summary, our results suggest that TRMT112 might be a potential prognostic predictor of cancers and involved in regulating multiple cancer-related immune responses to some extent.