Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape

Drug Deliv. 2022 Dec;29(1):2912-2924. doi: 10.1080/10717544.2022.2120565.

Abstract

Vaccinations, especially DNA vaccines that promote host immunity, are the most effective interventions for tuberculosis (TB) control. However, the vaccine delivery system exhibits a significant impact on the protective effects of the vaccine. Recently, effective nanomaterial-based delivery systems (including nanoparticles, nanogold, nanoliposomes, virus-like particles, and virus carriers) have been developed for DNA vaccines to control TB. This review highlights the historical development of various nanomaterial-based delivery systems for TB DNA vaccines, along with the emerging technologies. Nanomaterial-based vaccine delivery systems could enhance the efficacy of TB vaccination; therefore, this summary could guide nanomaterial selection for optimal and safe vaccine delivery, facilitating the design and development of highly effective TB vaccines.

Keywords: DNA vaccine; Mycobacterium tuberculosis; drug delivery; immune response; nanomaterials.

Publication types

  • Review

MeSH terms

  • DNA
  • Humans
  • Mycobacterium tuberculosis*
  • Nanostructures*
  • Tuberculosis Vaccines*
  • Tuberculosis* / prevention & control
  • Vaccination
  • Vaccines, DNA*

Substances

  • Tuberculosis Vaccines
  • Vaccines, DNA
  • DNA

Grants and funding

This research was supported by the Natural Science Foundation of Hunan Province (No. 2019JJ40321), Scientific Research Project of Hunan Provincial Health Commission (No. 20201933), National Natural Science Foundation Program of China (Nos. 32000651, 31670938, and 32070924), and Natural Science Foundation Project Program of Chongqing (Nos. 2022jcyjA1312, 2019jcyjA-msxmx0159 and 2014jcyjA0107). We thank LetPub (www.letpub.com) for linguistic assistance during the preparation of this manuscript.