Fetal Exposure to Air Pollution in Late Pregnancy Significantly Increases ADHD-Risk Behavior in Early Childhood

Abstract

Background: Air pollution nowadays has seriously threatened the health of the Chinese population, especially in the vulnerable groups of fetuses, infants and toddlers. In particular, the effects of air pollution on children's neurobehavioral development have attracted widespread attention. Moreover, the early detection of a sensitive period is very important for the precise intervention of the disease. However, such studies focusing on hyperactive behaviors and susceptible window identification are currently lacking in China.

Objectives: The study aims to explore the correlation between air pollution exposure and hyperactive behaviors during the early life stage and attempt to identify whether a susceptible exposure window exists that is crucial for further precise intervention.

Methods: Based on the Longhua Child Cohort Study, we collected the basic information and hyperactivity index of 26,052 children using a questionnaire conducted from 2015 to 2017, and the Conners' Parent Rating Scale-revised (CPRS-48) was used to assess hyperactive behaviors. Moreover, the data of air pollution concentration (PM₁₀, PM_2.5, NO₂, CO, O₃ and SO₂) were collected from the monitoring station between 2011 to 2017, and a land-use random forest model was used to evaluate the exposure level of each subject. Furthermore, Distributed lag non-linear models (DLNMs) were applied for statistic analysis.

Results: The risk of child hyperactivity was found to be positively associated with early life exposure to PM₁₀, PM_2.5 and NO₂. In particular, for an increase of per 10 µg/m³ in PM₁₀, PM_2.5 and NO₂ exposure concentration during early life, the risk of child hyperactivity increased significantly during the seventh month of pregnancy to the fourth month after birth, with the strongest association in the ninth month of pregnancy (PM₁₀: OR = 1.043, 95% CI: 1.016-1.071; PM_2.5: OR = 1.062, 95% CI: 1.024-1.102; NO₂: OR = 1.043, 95% CI: 1.016-1.071). However, no significant associations among early life exposure to CO, O₃ and SO₂ and child hyperactive behaviors were observed.

Conclusions: Early life exposure to PM₁₀, PM_2.5 and NO₂ is associated with an increased risk of child ADHD-like behaviors at the age around 3 years, and the late-prenatal and early postnatal periods might be the susceptible exposure windows.

Keywords: ADHD-like behavior; air pollution; fetal exposure.