A Review of Signaling Transduction Mechanisms in Osteoclastogenesis Regulation by Autophagy, Inflammation, and Immunity

Xishuai Tong; Gengsheng Yu; Xiaohui Fu; Ruilong Song; Jianhong Gu; Zongping Liu

doi:10.3390/ijms23179846

A Review of Signaling Transduction Mechanisms in Osteoclastogenesis Regulation by Autophagy, Inflammation, and Immunity

Int J Mol Sci. 2022 Aug 30;23(17):9846. doi: 10.3390/ijms23179846.

Authors

Xishuai Tong^{1

2

3}, Gengsheng Yu^{1

2

3}, Xiaohui Fu^{1

2

3}, Ruilong Song^{1

2

3}, Jianhong Gu^{1

2

3}, Zongping Liu^{1

2

3}

Affiliations

¹ Institutes of Agricultural Science and Technology Development (Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China)/College of Veterinary Medicine, Yangzhou 225009, China.
² Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
³ Jiangsu Key Laboratory of Zoonosis, Yangzhou 225009, China.

Abstract

Osteoclastogenesis is an ongoing rigorous course that includes osteoclast precursors fusion and bone resorption executed by degradative enzymes. Osteoclastogenesis is controlled by endogenous signaling and/or regulators or affected by exogenous conditions and can also be controlled both internally and externally. More evidence indicates that autophagy, inflammation, and immunity are closely related to osteoclastogenesis and involve multiple intracellular organelles (e.g., lysosomes and autophagosomes) and certain inflammatory or immunological factors. Based on the literature on osteoclastogenesis induced by different regulatory aspects, emerging basic cross-studies have reported the emerging disquisitive orientation for osteoclast differentiation and function. In this review, we summarize the partial potential therapeutic targets for osteoclast differentiation and function, including the signaling pathways and various cellular processes.

Keywords: autophagy; immunity; inflammation; osteoclastogenesis.

Publication types

Review

MeSH terms

Autophagy
Bone Resorption* / metabolism
Cell Differentiation
Humans
Inflammation / metabolism
Osteoclasts / metabolism
Osteogenesis*
RANK Ligand / metabolism

Substances

RANK Ligand

Grants and funding

This work was supported by National Natural Science Foundation of China grant numbers 32102732, 31872533 and 31872534, Natural Science Foundation of Jiangsu Province grant number BK20210806, the Open Project Program of the Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University (JILAR-KF202110), and was funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).