Acupuncture can regulate peripheral inflammatory response mainly through somatosensory-vagal/sympathetic nerve-splenic/adrenal/local reflex pathway. Besides, acupuncture may also play an anti-inflammatory role through gut microbiota and neuro-endocrine pathway. The effects of acupuncture have acupoint specificity and time window effect, and are influenced by voltage, current and frequency of electroacupuncture. Future research should focus on the connection and interaction of multiple targets, pathways and mechanisms in the brain, and clarify the multi-target advantages of acupuncture anti-inflammatory.
针刺主要通过躯体感觉神经-迷走/交感神经-脾/肾上腺/局部反射通路发挥调节外周炎性反应效应，还能通过肠道菌群和神经-内分泌通路产生作用。针刺的作用具有穴位特异性和时间窗效应，且受电针的电压/电流/频率影响。未来研究应关注多靶点、多途径、多机制在脑中的联系与交互，明确针刺抗炎的多靶点优势。.
Keywords: acupuncture; anti-inflammation; autonomic nerve; gut microbiota; inflammatory response; neuro-endocrine pathway.