Left atrial myocardial intrinsic function remodeling response to repair of primary mitral regurgitation

Echocardiography. 2022 Oct;39(10):1264-1268. doi: 10.1111/echo.15452. Epub 2022 Sep 8.

Abstract

Severe mitral regurgitation (MR) is a common valve disease which is associated with high mortality, if only managed medically. MR produces chronic and progressive volume overload with left atrial (LA) and left ventricular (LV) dilatation and dysfunction, atrial fibrillation (AF) and eventually myocardial fibrosis, irrespective of ejection fraction (EF). Surgical correction (mitral valve repair) of MR removes the volume overload, hence unmasks pre-operative LV structure and function disturbances, including reduced EF and global longitudinal and circumferential strain, as well as LA volume and strain. This review aims at describing LA remodeling before and after surgical repair.

Keywords: echocardiography; left atrial; left ventricular; mitral regurgitation; remodeling.

Publication types

  • Review

MeSH terms

  • Atrial Function, Left
  • Atrial Remodeling* / physiology
  • Heart Atria / diagnostic imaging
  • Humans
  • Mitral Valve Insufficiency* / diagnostic imaging
  • Mitral Valve Insufficiency* / surgery
  • Ventricular Dysfunction, Left*
  • Ventricular Function, Left / physiology