Multifunctional exosomes derived from bone marrow stem cells for fulfilled osseointegration

Jingwen Zhuang; Ruiyue Hang; Ruoyue Sun; Yanshu Ding; Xiaohong Yao; Ruiqiang Hang; Hui Sun; Long Bai

doi:10.3389/fchem.2022.984131

Multifunctional exosomes derived from bone marrow stem cells for fulfilled osseointegration

Front Chem. 2022 Aug 22:10:984131. doi: 10.3389/fchem.2022.984131. eCollection 2022.

Authors

Jingwen Zhuang¹, Ruiyue Hang², Ruoyue Sun¹, Yanshu Ding¹, Xiaohong Yao², Ruiqiang Hang², Hui Sun³, Long Bai^{4

5}

Affiliations

¹ Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.
² Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, China.
³ Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
⁴ Institute of Translational Medicine, Shanghai University, Shanghai, China.
⁵ Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.

Abstract

Bone marrow mesenchymal stem cells (BMSCs) have self-renewal, multi-directional differentiation potential, and immune regulation function and are widely used for de novo bone formation. However, the wide variation in individual amplification, the potential risk of cancer cell contamination, and the need for culture time significantly limit their widespread use clinically. Alternatively, numerous studies have shown that exosomes secreted by BMSCs in the nanoscale can also affect the functionality of endothelial cells (angiogenesis), macrophages (immunomodulation), and osteoblasts/osteoclasts (osteogenesis), which is a highly promising therapy for osseointegration with pronounced advantages (e.g., safety, high efficiency, and no ethical restrictions). The review aims to summarize the multifaceted effect of BMSCs-derived exosomes on osseointegration and provide reference and basis for rapid and qualified osseointegration.

Keywords: angiogenesis; bone marrow mesenchymal stem cells; exosomes; immunomodulation; osteogenesis.

Publication types

Review