Correlation between TCM Constitutional Types and Lung Carcinoma in Various Geographical Areas: A Systematic Review and Meta-Analysis

Xinyu Yu; Lei Yan; Qin Lan; Lilin Wan; Jun Xiong; Leichang Zhang; Huyun Nie; Zhaohui Ding

doi:10.1155/2022/5660231

Correlation between TCM Constitutional Types and Lung Carcinoma in Various Geographical Areas: A Systematic Review and Meta-Analysis

Contrast Media Mol Imaging. 2022 Aug 17:2022:5660231. doi: 10.1155/2022/5660231. eCollection 2022.

Authors

Xinyu Yu¹, Lei Yan², Qin Lan¹, Lilin Wan³, Jun Xiong⁴, Leichang Zhang⁵, Huyun Nie⁶, Zhaohui Ding³

Affiliations

¹ Center for Treatment of Diseases, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
² Ophthalmology Department, Jiangxi Integrated Hospital of Traditional Chinese and Western Medicine, Nanchang, Jiangxi, China.
³ Pulmonary Disease Department, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
⁴ Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
⁵ Department of Proctology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
⁶ Evidence-Based Medicine Research Centre, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.

Abstract

Background: Lung carcinoma is a serious disorder that negatively influences the quality of life of sufferers. Despite the growing number of investigations into the management and prognosis of lung carcinoma, few research studies have been conducted to demonstrate the association between TCM constitution and lung carcinoma.

Methods: We searched PubMed, EMBASE, Science Net, Cochrane Library, China National Knowledge Infrastructure, VIP database, Wanfang database, and China Biomedical Literature Database for Chinese and English versions until January 31, 2021. We also manually searched for Chinese lung cancer, Chinese physical medicine, Chinese medical trial registries, and unpublished surveys or references. The literature was screened against inclusive and exclusive criteria, and two investigators' results were independently summarized. The primary outcome was a ratio of body type. Single-group rates were meta-analyzed using Stata 14.0 statistical software, bias was estimated by funnel plotting, and sources of heterogeneity were evaluated by subgroup and sensitivity examinations.

Results: 18 randomized controlled trials were totally included to compare the single-group ratio and 95% confidence interval of nine constitution types of lung cancer, namely, mild constitution (ES = 0.12, 95% CI (0.08, 0.15), P < 0.0001), Qi deficiency constitution (ES = 0.20, 95% CI (0.15, 0.26), P < 0.0001), Qi depression constitution (ES = 0.09, 95% CI (0.07, 0.12), P < 0.0001), damp-heat constitution (ES = 0.05, 95% CI (0.03, -0.06), P < 0.0001), phlegm dampness constitution (ES = 0.05, 95% CI (0.03, -0.06), P < 0.0001), special constitution (ES = 0.01, 95% CI (0.01, 0.02), P=0.993), blood stasis constitution (ES = 0.05, 95% CI (0.04, 0.07), P < 0.0001), Yang deficiency constitution (ES = 0.16, 95% CI (0.12, 0.19), P < 0.0001), and Yin deficiency constitution (MD = 0.15, 95% CI (0.11, 0.18), P < 0.0001).

Conclusion: This study showed that Qi deficiency, Yang deficiency, and Yin vacuity were the predominant types of physical conditions of lung cancer cases.

Publication types

Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Body Constitution
Carcinoma*
Humans
Lung
Lung Neoplasms* / diagnosis
Lung Neoplasms* / epidemiology
Medicine, Chinese Traditional / methods
Quality of Life