PET/CT Evaluation of the Effect of Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of T-Cell Lymphoblastic Lymphoma

Contrast Media Mol Imaging. 2022 Aug 16:2022:6057017. doi: 10.1155/2022/6057017. eCollection 2022.

Abstract

The aim of this study was to investigate the clinical value of positron emission tomography/computerized tomography scanning (PET/CT) in the evaluation of the effect of allogeneic hematopoietic stem cell transplantation in the treatment of T lymphoblastic lymphoma. 12 relevant research articles were collected through layer-by-layer screening in large databases such as Pubmed, Baidu Scholar, and China How Net, and analyzed and summarized using indicators such as progression-free survival (PFS), overall survival (OS), hazard ratio (HR), maximum standardized uptake value (SUV max), total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), elevated lactate dehydrogenase (LDH), and β2-microglobulin (β2-MG). The results showed that before treatment, 18F-FDG PET/CT baseline diagnosis could accurately stage the patients; during treatment, 18F-FDG PET/CT detection could provide effective treatment information; and after treatment, complications were found during 18F-FDG PET/CT detection. In summary, 18F-FDG PET/CT can monitor and evaluate treatment prognosis at baseline, middle, and late stages, and 18F-FDG PET/CT has become an indispensable and important examination technique in clinical work.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorodeoxyglucose F18 / metabolism
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Positron Emission Tomography Computed Tomography / methods
  • Positron-Emission Tomography
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma*
  • Radiopharmaceuticals / metabolism
  • T-Lymphocytes / metabolism

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18