The Correlation Between Estimated Glucose Disposal Rate and Coagulation Indexes in Type 2 Diabetes Mellitus

Zelin Li; Cuijuan Qi; Zhuoya Jia; Ruoxi Zhen; Lin Ren; Yujiao Jia; Shuchun Chen

doi:10.2147/DMSO.S371457

The Correlation Between Estimated Glucose Disposal Rate and Coagulation Indexes in Type 2 Diabetes Mellitus

Diabetes Metab Syndr Obes. 2022 Aug 31:15:2643-2652. doi: 10.2147/DMSO.S371457. eCollection 2022.

Authors

Zelin Li^{1

2}, Cuijuan Qi¹, Zhuoya Jia^{1

2}, Ruoxi Zhen^{1

2}, Lin Ren^{1

3}, Yujiao Jia^{1

2}, Shuchun Chen^{1

2

4}

Affiliations

¹ Graduate School of Hebei Medical University, People's Republic of China.
² Department of Endocrinology, Hebei General Hospital, People's Republic of China.
³ North China University of Science and Technology, People's Republic of China.
⁴ Hebei Key Laboratory of Metabolic Diseases, People's Republic of China.

Abstract

Purpose: To study the correlation between estimated glucose disposition rate (eGDR) and coagulation parameters in type 2 diabetes patients (T2DM).

Materials and methods: A total of 948 patients suffering from T2DM were enrolled for this research. Various blood coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) were assessed. Body mass index (BMI), hypertension, and the levels of glycated hemoglobin (HbA1c) were used to calculate the patients' eGDRs. All patients were sorted into two groups: those with high eGDRs (eGDR≥7.5) and those with low eGDRs (eGDR<7.5). The patients were then separated into groups of men and women. The connection between eGDR and coagulation indexes was examined using Spearman correlation, Pearson correlation, and multiple linear regression analysis.

Results: In comparison to the high-eGDR group, reduced PT and APTT levels with increased FIB levels were observed in the low-eGDR group (P =0.006, P <0.001, and P = 0.035, respectively). The eGDR showed a positive relation with APTT (r = 0.142, P < 0.001), a negative relation with FIB (r = -0.082, P = 0.012), and no correlation with PT (r =0.064, P =0.050) in the all patients. As well as, the eGDR demonstrated a positive relation with APTT (r = 0.173, P < 0.001), a negative relation with FIB (r = -0.093, P = 0.03), and no relation with PT (r = 0.045, P = 0.300) in the male subgroups. Additionally, this correlation persisted following the adjustment of other factors in multilinear regression analysis. However, the female subgroup demonstrated no correlation among eGDR and PT, APTT or FIB (r = 0.086, P = 0.083, r = 0.097, P = 0.05;r = -0.058, P = 0.240, respectively).

Conclusion: Our study is the first to prove that eGDR demonstrates a correlation with coagulation indexes in T2DM patients. And, this correlation is gender-specific.

Keywords: coagulation indexes; estimated glucose disposal rate; type 2 diabetes mellitus.