Camels' biological fluids contained nanobodies: promising avenue in cancer therapy

Nouf S Al-Numair; Abdulrahman Theyab; Faisal Alzahrani; Anwar M Shams; Ibrahim O Al-Anazi; Atif Abdulwahab A Oyouni; Osama M Al-Amer; Charalampos Mavromatis; Islam M Saadeldin; Wed A Abdali; Yousef M Hawsawi

doi:10.1186/s12935-022-02696-7

Camels' biological fluids contained nanobodies: promising avenue in cancer therapy

Cancer Cell Int. 2022 Sep 7;22(1):279. doi: 10.1186/s12935-022-02696-7.

Authors

Nouf S Al-Numair^{1

2}, Abdulrahman Theyab^{3

4}, Faisal Alzahrani^{5

6}, Anwar M Shams⁷, Ibrahim O Al-Anazi⁸, Atif Abdulwahab A Oyouni^{9

10}, Osama M Al-Amer¹¹, Charalampos Mavromatis¹², Islam M Saadeldin¹³, Wed A Abdali⁹, Yousef M Hawsawi^{14

15}

Affiliations

¹ Center of Genomic Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
² College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh, 11533, Saudi Arabia.
³ Department of Laboratory & Blood Bank, Security Forces Hospital, P.O. Box 14799, Mecca, 21955, Saudi Arabia.
⁴ College of Medicine, Al-Faisal University, P.O. Box 50927, Riyadh, 11533, Saudi Arabia.
⁵ Department of Biochemistry, Faculty of Science, Embryonic Stem Cells Unit, King Fahad Medical Center, King Abdulaziz University, Jeddah, Saudi Arabia.
⁶ Centre of Artificial Intelligence in Precision Medicines (CAIPM), King Abdulaziz University, Jeddah, Saudi Arabia.
⁷ Department of Pharmacology, College of Medicine, Taif University, P.O. BOX 11099, Taif, 21944, Saudi Arabia.
⁸ The National Center for Genomic Technology, King Abdulaziz City for Science and Technology, P.O Box 6086, Riyadh, 11442, Saudi Arabia.
⁹ Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.
¹⁰ Genome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.
¹¹ Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
¹² Department of Biological Sciences, Faculty of Science and Arts (Rabigh Campus), King Abdulaziz University, Jeddah, Saudi Arabia.
¹³ Research Institute of Veterinary Medicine, Chungam National University, Daejeon, 34134, Korea.
¹⁴ College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh, 11533, Saudi Arabia. hyousef@kfshrc.edu.sa.
¹⁵ Research Center, King Faisal Specialist Hospital and Research Center, MBC-J04, PO Box 40047, Jeddah, 21499, Saudi Arabia. hyousef@kfshrc.edu.sa.

Abstract

Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies are characteristically small-sized biologics featured with the ability for deep tissue penetration and dissemination and harbour high stability at high pH and temperatures. The current review highlights the potential use of nanobodies that are naturally secreted in camels' biological fluids, both milk and urine, in the development of nanotechnology-based therapy for treating different typesQuery of cancers and other diseases. Moreover, the role of nano proteomics in the invention of novel therapeutic agents specifically used for cancer intervention is also illustrated.

Keywords: And nano proteomics; Arabian camelid; Biological fluids; Cancers; Diagnosis; Nanobodies; Therapeutic agents.

Publication types

Review