A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model

Kexin Chen; Silan Shen; Yiding Chen; Mingshan Jiang; Kehan Hu; Yuheng Zou; Lili Li; Zhen Zeng; Chunxiang Ma; Yuan Dang; Hu Zhang

doi:10.1038/s41597-022-01637-3

A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model

Sci Data. 2022 Sep 7;9(1):549. doi: 10.1038/s41597-022-01637-3.

Authors

Kexin Chen^#^{1

2

3}, Silan Shen^#^{1

2

3}, Yiding Chen¹, Mingshan Jiang^{1

2

3}, Kehan Hu^{1

2

3}, Yuheng Zou^{1

2

3}, Lili Li^{1

2

3}, Zhen Zeng^{1

2

3}, Chunxiang Ma^{1

2

3}, Yuan Dang^{1

2

3}, Hu Zhang^{4

5

6}

Affiliations

¹ Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
² Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.
³ Laboratory of Inflammatory Bowel Disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
⁴ Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China. zhanghu@scu.edu.cn.
⁵ Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China. zhanghu@scu.edu.cn.
⁶ Laboratory of Inflammatory Bowel Disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. zhanghu@scu.edu.cn.

^# Contributed equally.

Abstract

An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaicin is strongly associated with the recurrence and worsening of IBD symptoms. Moreover, capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration. To uncover the potential signaling pathway involved in capsaicin-induced relapse and the effects of capsaicin on neutrophil activation, we performed proteomic analyses of intestinal tissues from chronic colitis mice following capsaicin administration and transcriptomic analyses of dHL-60 cells after capsaicin stimulation. Collectively, these multiomic analyses identified proteins and genes that may be involved in disease flares, thereby providing new insights for future research.

Publication types

Dataset

MeSH terms

Animals
Capsaicin
Chronic Disease
Colitis* / genetics
Colitis* / metabolism
Dextran Sulfate / adverse effects
Disease Models, Animal
Inflammatory Bowel Diseases*
Mice
Mice, Inbred C57BL
Proteomics
RNA-Seq
Transcriptome

Substances

Dextran Sulfate
Capsaicin