A brown fat-selective mechanism of mitochondrial calcium import?

Janane F Rahbani; Lawrence Kazak

doi:10.1016/j.cmet.2022.08.011

A brown fat-selective mechanism of mitochondrial calcium import?

Cell Metab. 2022 Sep 6;34(9):1231-1233. doi: 10.1016/j.cmet.2022.08.011.

Authors

Janane F Rahbani¹, Lawrence Kazak²

Affiliations

¹ Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
² Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada. Electronic address: lawrence.kazak@mcgill.ca.

PMID: 36070679
DOI: 10.1016/j.cmet.2022.08.011

Abstract

In this issue of Cell Metabolism, Xue et al. propose that the mitochondrial calcium uniporter (MCU) binds uncoupling protein 1 (UCP1) via the MCU regulator (EMRE) to form a protein complex that the authors term the "thermoporter." Through gain- and loss-of-function experiments, the authors infer that the thermoporter promotes calcium influx into the mitochondrial matrix to enhance NADH production, which supports thermogenesis in brown adipose tissue (BAT).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adipose Tissue, Brown* / metabolism
Calcium* / metabolism
Mitochondria / metabolism
Thermogenesis
Uncoupling Protein 1 / metabolism

Substances

Uncoupling Protein 1
Calcium

Abstract

Publication types

MeSH terms

Substances

Grants and funding