Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration

Matheus B Victor; Li-Huei Tsai

doi:10.1016/j.cmet.2022.08.013

Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration

Cell Metab. 2022 Sep 6;34(9):1227-1229. doi: 10.1016/j.cmet.2022.08.013.

Authors

Matheus B Victor¹, Li-Huei Tsai²

Affiliations

¹ Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
² Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: lhtsai@mit.edu.

PMID: 36070677
DOI: 10.1016/j.cmet.2022.08.013

Abstract

In this issue of Cell Metabolism, Traxler et al. report a metabolic switch in neurons that hinges on the critical balance of pyruvate kinase M (PKM) isoform ratios. Using directly induced neurons (iNs) derived from patients with Alzheimer's disease (AD), the work delineates the impact of an AD-specific switch from PKM1 to PKM2 onto neuronal resilience against neurodegeneration.

Publication types

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MeSH terms

Alzheimer Disease / pathology
Humans
Neurons* / metabolism
Pyruvate Kinase* / metabolism

Substances

Pyruvate Kinase