A photo-activated aptamer-drug conjugate for targeted drug delivery

Jing Liu; Xiangjun Liu; Mengwen Yi; Yue Sun; Tao Bing; Nan Zhang; Dihua Shangguan

doi:10.1039/d2cc04045j

A photo-activated aptamer-drug conjugate for targeted drug delivery

Chem Commun (Camb). 2022 Sep 27;58(77):10797-10800. doi: 10.1039/d2cc04045j.

Authors

Jing Liu^{1

2}, Xiangjun Liu^{1

2}, Mengwen Yi¹, Yue Sun¹, Tao Bing^{1

2}, Nan Zhang¹, Dihua Shangguan^{1

2

3}

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. xjliu@iccas.ac.cn.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.

PMID: 36069382
DOI: 10.1039/d2cc04045j

Abstract

A photo-activated aptamer-drug conjugate, HG1-9-DNP, was developed based on an aptamer HG1-9 and a photolabile naphthalimide derivative DNP. HG1-9-DNP could be internalized into cells mediated by TfR, then photocleaved, and released a promising cytotoxic agent, DNNH, which arrested the cell cycle at the G2/M phase, resulting in high photo-induced cytotoxicity.

MeSH terms

Aptamers, Nucleotide* / metabolism
Aptamers, Nucleotide* / pharmacology
Cell Line, Tumor
Cytotoxins
Doxorubicin* / pharmacology
Drug Delivery Systems / methods
Naphthalimides
Oligonucleotides
Pharmaceutical Preparations

Substances

Aptamers, Nucleotide
Cytotoxins
Naphthalimides
Oligonucleotides
Pharmaceutical Preparations
Doxorubicin