RNA editing in Mycobacterium tuberculosis

Yan Guo; Yuri F van der Heijden; Fernanda Maruri; Limin Jiang; Robert Morrison; Timothy R Sterling

doi:10.1016/j.micres.2022.127174

RNA editing in Mycobacterium tuberculosis

Microbiol Res. 2022 Nov:264:127174. doi: 10.1016/j.micres.2022.127174. Epub 2022 Aug 23.

Authors

Yan Guo¹, Yuri F van der Heijden², Fernanda Maruri³, Limin Jiang¹, Robert Morrison⁴, Timothy R Sterling⁵

Affiliations

¹ Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
² Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, USA; The Aurum Institute, Johannesburg, South Africa.
³ Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
⁴ Seattle Children's Hospital, Seattle, WA, USA.
⁵ Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: timothy.sterling@vumc.org.

PMID: 36067705
DOI: 10.1016/j.micres.2022.127174

Abstract

RNA editing, while studied thoroughly in humans, has been sporadically described in bacteria, and to our knowledge, has not been reported in Mycobacterium tuberculosis (Mtb). After thorough quality control and validation by repeated sequencing, by comparing sequences from RNA and DNA from high-throughput sequencing data, we report the first finding of three RNA editing events in two Mtb isolates.

Keywords: M. tuberculosis; RNA editing.

Publication types

Review

MeSH terms

High-Throughput Nucleotide Sequencing
Humans
Mycobacterium tuberculosis* / genetics
RNA Editing / genetics