Polyester nanomedicines targeting inflammatory signaling pathways for cancer therapy

Sabya Sachi Das; Sandeep Kumar Singh; P R P Verma; Rekha Gahtori; Belay Zeleke Sibuh; Kavindra Kumar Kesari; Niraj Kumar Jha; Sugapriya Dhanasekaran; Vijay Kumar Thakur; Ling Shing Wong; Sinouvassane Djearamane; Piyush Kumar Gupta

doi:10.1016/j.biopha.2022.113654

Polyester nanomedicines targeting inflammatory signaling pathways for cancer therapy

Biomed Pharmacother. 2022 Oct:154:113654. doi: 10.1016/j.biopha.2022.113654. Epub 2022 Sep 5.

Affiliations

¹ Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology - Mesra, Ranchi 835215, Jharkhand, India; School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun 248009, Uttarakhand, India.
² Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology - Mesra, Ranchi 835215, Jharkhand, India. Electronic address: sandeep.singh@bitmesra.ac.in.
³ Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology - Mesra, Ranchi 835215, Jharkhand, India.
⁴ Department of Biotechnology, Sir J. C. Bose Technical Campus, Kumaun University, Bhimtal, Nainital 263136, Uttarakhand, India.
⁵ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida 201310, Uttar Pradesh, India.
⁶ Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo 00076, Finland; Department of Applied Physics, Aalto University, Espoo, Finland.
⁷ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida 201310, Uttar Pradesh, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, Uttarakhand, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India.
⁸ Medical Laboratory Sciences Department, College of Applied Medical Sciences, University of Bisha, Bisha 67714, Saudi Arabia.
⁹ Biorefining and Advanced Materials Research Centre, SRUC, Edinburgh EH9 3JG, United Kingdom; School of Engineering, University of Petroleum & Energy Studies (UPES), Dehradun 248007, Uttarakhand, India; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun 248002, Uttarakhand, India.
¹⁰ Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia. Electronic address: lingshing.Wong@newinti.edu.my.
¹¹ Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia. Electronic address: sinouvassane@utar.edu.my.
¹² Department of Life Sciences, Sharda School of Basic Sciences and Research, Sharda University, Greater Noida 201310, Uttar Pradesh, India; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun 248002, Uttarakhand, India. Electronic address: dr.piyushkgupta@gmail.com.

PMID: 36067568
DOI: 10.1016/j.biopha.2022.113654

Abstract

The growth of cancerous cells and their responses towards substantial therapeutics are primarily controlled by inflammations (acute and chronic) and inflammation-associated products, which either endorse or repress tumor progression. Additionally, major signaling pathways, including NF-κB, STAT3, inflammation-causing factors (cytokines, TNF-α, chemokines), and growth-regulating factors (VEGF, TGF-β), are vital regulators responsible for the instigation and resolution of inflammations. Moreover, the conventional chemotherapeutics have exhibited diverse limitations, including poor pharmacokinetics, unfavorable chemical properties, poor targetability to the disease-specific disease leading to toxicity; thus, their applications are restricted in inflammation-mediated cancer therapy. Furthermore, nanotechnology has demonstrated potential benefits over conventional chemotherapeutics, such as it protected the incorporated drug/bioactive moiety from enzymatic degradation within the systemic circulation, improving the physicochemical properties of poorly aqueous soluble chemotherapeutic agents, and enhancing their targetability in specified carcinogenic cells rather than accumulating in the healthy cells, leading reduced cytotoxicity. Among diverse nanomaterials, polyester-based nanoparticulate delivery systems have been extensively used to target various inflammation-mediated cancers. This review summarizes the therapeutic potentials of various polyester nanomaterials (PLGA, PCL, PLA, PHA, and others)-based delivery systems targeting multiple signaling pathways related to inflammation-mediated cancer.

Keywords: Anticancer; Inflammatory signaling pathways; Nanomedicine; Polyester nanomaterials; Targeted delivery.

Publication types

Review

MeSH terms

Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Antineoplastic Agents* / therapeutic use
Drug Delivery Systems
Humans
Inflammation / drug therapy
Nanomedicine
Neoplasms* / pathology
Polyesters
Signal Transduction

Substances

Antineoplastic Agents
Polyesters