Innatus immunis: Evolving paradigm of adaptive NK cells

J Exp Med. 2022 Nov 7;219(11):e20221254. doi: 10.1084/jem.20221254. Epub 2022 Sep 6.

Abstract

The mechanisms that govern the development of adaptive-like NK cells are elusive. Shemesh et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220551) report that the development of FcRγ-/low adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α. These findings provide exciting new molecular blueprints explaining the development and functions of adaptive-like NK cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Killer Cells, Natural*
  • Transforming Growth Factor beta*

Substances

  • Transforming Growth Factor beta