Innovation is essential around the themes of climate change and sustainability. Commercial photovoltaics (PV) have noticeably contributed to getting to 22.1% share of the gross final energy consumption in Europe from renewable sources in 2020 but a steep further increase is urgent in the near future. Over the last few years, great success has been achieved by perovskites applied to PV, with mixed anions and cations in shared lattices that reached record efficiency values close to those of Si in laboratory-scale solar cells (∼26%). Their use has recently shed light on a medium/long-term compositional instability that arises from the partial miscibility of the species with similar role in the atomic lattice. The chemical route to prepare the materials for Perovskite Solar Cells (PSCs) also needs to be critically reviewed. Material waste and reuse are other concerns to be faced. This perspective paper indeed tackles some aspects for innovation and sustainability on the PSC field for production purposes. Some hints for technologically affordable processes based on in-vacuum deposition of Perovskites are provided in light of their sustainability and for the need to reduce production/maintenance costs. It is also discussed how to make in-vacuum production further competitive by boosting the material quality. Innovation is also projected into the theme of making sustainable choices for device architectures and materials. Carbon-based PSCs are highly focused since they allow avoiding the use of complex, unstable and costly HTLs. From the material side, pros and cons of using fully inorganic CsPbI3 are commented, framed by the current revival of single-cation perovskites. CsPbI3, in particolar, enables recycling and reuse initiatives thanks to the overall mass preservation under degradation. Some closing remarks are provided on the safe use of Pb as its effective sequestration before release from the PSC into the environment is properly engineered. We lastly trust that initiatives bringing together academic and industrial know-how in complementary fields able to take up responsible innovation will contribute to accelerating the ecological transition and will enable the societal transformation to fulfil the 2050 EU agenda for a sustainable future.