Spirulina polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice

Yingfang Lu; Bo Peng; Yuqi Lin; Qianmin Lin; Xuewei Xia; Saiyi Zhong; Lianxiang Luo; Riming Huang

doi:10.1016/j.crfs.2022.08.010

Spirulina polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice

Curr Res Food Sci. 2022 Aug 24:5:1313-1319. doi: 10.1016/j.crfs.2022.08.010. eCollection 2022.

Authors

Yingfang Lu¹, Bo Peng^{2

3}, Yuqi Lin¹, Qianmin Lin¹, Xuewei Xia¹, Saiyi Zhong⁴, Lianxiang Luo⁵, Riming Huang¹

Affiliations

¹ Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China.
² State Key Laboratory of Organic Geochemistry, Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China, CAS Center for Excellence in Deep Earth Science, Guangzhou, 510640, China.
³ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁴ College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Province Engineering Laboratory for Marine Biological Products, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang, 524088, China.
⁵ The Marine Biomedical Research Institute, Guangdong Medical University, The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524000, China.

Abstract

A polysaccharide obtained from Spirulina (PSP) and its effect on lung cancer in mice was investigated. Our results indicate that the tumor volume and weight of the lung cancer-bearing mice treated with PSP decreased significantly. Metabolite analysis showed that 27 differential accumulated metabolites (DAMs) changed significantly, in which 24 DAMs increased while 3 DAMs decreased. KEGG enrichment results showed that these differential metabolites were enriched significantly in the high-affinity IgE receptor (FcεRI) signaling pathway and arachidonic acid metabolism. In addition, PSP modulated gut microbiota of the lung cancer-bearing mice. PSP increased the abundance of Lactobacillus, Allobaculum, Alloprevotella, and Olsenella, decreasing Bacteroides and Acinetobacter. The results might be related to suppressing lung cancer. Based on our study, we hypothesized that PSP inhibited lung cancer through FcεRI signaling pathway and arachidonic acid metabolism and regulated the balance of gut microbiota. Nevertheless, the relationship between these two pathways and gut microbiota needs further study.

Keywords: Gut microbiota; Lung cancer; Metabolomics; Polysaccharide; Spirulina.