Connecting chemical exposome to human health using high-resolution mass spectrometry-based biomonitoring: Recent advances and future perspectives

Yuan-Chih Chen; Jing-Fang Hsu; Chih-Wei Chang; Shih-Wen Li; Ya-Chi Yang; Mu-Rong Chao; Hauh-Jyun C Chen; Pao-Chi Liao

doi:10.1002/mas.21805

Connecting chemical exposome to human health using high-resolution mass spectrometry-based biomonitoring: Recent advances and future perspectives

Mass Spectrom Rev. 2023 Nov-Dec;42(6):2466-2486. doi: 10.1002/mas.21805. Epub 2022 Sep 5.

Authors

Yuan-Chih Chen¹, Jing-Fang Hsu², Chih-Wei Chang¹, Shih-Wen Li¹, Ya-Chi Yang¹, Mu-Rong Chao^{3

4}, Hauh-Jyun C Chen⁵, Pao-Chi Liao^{1

6}

Affiliations

¹ Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan.
² National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
³ Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan.
⁴ Department of Occupational Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
⁵ Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan.
⁶ Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

PMID: 36062854
DOI: 10.1002/mas.21805

Abstract

Compared with the rapid advances in genomics leading to broad understanding of human disease, the linkage between chemical exposome and diseases is still under investigation. High-resolution mass spectrometry (HRMS) is expected to accelerate the process via relatively accurate and precise biomonitoring of human exposome. This review covers recent advancements in biomonitoring of exposed environmental chemicals (chemical exposome) using HRMS described in the 124 articles that resulted from a systematic literature search on Medline and Web of Science databases. The analytical strategic aspects, including the selection of specimens, sample preparation, instrumentation, untargeted versus targeted analysis, and workflows for MS-based biomonitoring to explore the environmental chemical space of human exposome, are deliberated. Applications of HRMS in human exposome investigation are presented by biomonitoring (1) exposed chemical compounds and their biotransformation products; (2) DNA/protein adducts; and (3) endogenous compound perturbations. Challenges and future perspectives are also discussed.

Keywords: DNA/protein adducts; biomonitoring; biotransformation products; exposome; high resolution mass spectrometry.

Publication types

Review