Core-Shell Polydopamine/Cu Nanometer Rods Efficiently Deactivate Microbes by Mimicking Chloride-Activated Peroxidases

Lian-Jiao Zhou; Yu-Ying Wang; Shu-Lan Li; Ling Cao; Feng-Lei Jiang; Thomas Maskow; Yi Liu

doi:10.1021/acsomega.2c02986

Core-Shell Polydopamine/Cu Nanometer Rods Efficiently Deactivate Microbes by Mimicking Chloride-Activated Peroxidases

ACS Omega. 2022 Aug 17;7(34):29984-29994. doi: 10.1021/acsomega.2c02986. eCollection 2022 Aug 30.

Authors

Lian-Jiao Zhou¹, Yu-Ying Wang¹, Shu-Lan Li^{1

2}, Ling Cao¹, Feng-Lei Jiang¹, Thomas Maskow³, Yi Liu^{1

2}

Affiliations

¹ Department of Chemistry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
² State Key Laboratory of Membrane Separation and Membrane Process & Tianjin Key Laboratory of Green Chemical Technology and Process Engineering, School of Chemistry, Tiangong University, Tianjin 300387, P. R. China.
³ Department of Environmental Microbiology, UFZ, Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.

Abstract

Cu-modified nanoparticles have been designed to mimic peroxidase, and their potent antibacterial and anti-biofilm abilities have been widely investigated. In this study, novel core-shell polydopamine (PDA)/Cu₄(OH)₆SO₄ crystal (PDA/Cu) nanometer rods were prepared. The PDA/Cu nanometer rods show similar kinetic behaviors to chloride-activated peroxidases, exhibit excellent photothermal properties, and are sensitive to the concentrations of pH values and the substrate (i.e., H₂O₂). PDA/Cu nanometer rods could adhere to the bacteria and catalyze hydrogen peroxide (H₂O₂) to generate more reactive hydroxy radicals (^•OH) against Staphylococcus aureus and Escherichia coli, Furthermore, PDA/Cu nanometer rods show enhanced catalytic and photothermal synergistic antibacterial activity. This work provides a simple, inexpensive, and effective strategy for antibacterial applications.