Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS

Chang Liu; Kun Xiao; Lixin Xie

doi:10.3389/fimmu.2022.922702

Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS

Front Immunol. 2022 Aug 18:13:922702. doi: 10.3389/fimmu.2022.922702. eCollection 2022.

Authors

Chang Liu^{1

2

3}, Kun Xiao^{2

3}, Lixin Xie^{1

2

3}

Affiliations

¹ School of Medicine, Nankai University, Tianjin, China.
² College of Pulmonary & Critical Care Medicine, 8th Medical Center, Chinese PLA General Hospital, Beijing, China.
³ Medical School of Chinese PLA, Beijing, China.

Abstract

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality that poses a major challenge in critical care medicine. The development of ALI/ARDS involves excessive inflammatory response, and macrophage autophagy plays an important role in regulating the inflammatory response in ALI/ARDS. In this paper, we review the effects of autophagy in regulating macrophage function, discuss the roles of macrophage autophagy in ALI/ARDS, and highlight drugs and other interventions that can modulate macrophage autophagy in ALI/ARDS to improve the understanding of the mechanism of macrophage autophagy in ALI/ARDS and provide new ideas and further research directions for the treatment of ALI/ARDS.

Keywords: acute lung injury; acute respiratory distress syndrome; autophagy; macrophage; treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acute Lung Injury* / therapy
Autophagy
Critical Care
Humans
Macrophages
Respiratory Distress Syndrome*