Biochemical Status of Obese Male Adolescents of Different Ethnicity: Discriminant Analysis in the Identification of the Most Informative Indicators

Bull Exp Biol Med. 2022 Aug;173(4):459-463. doi: 10.1007/s10517-022-05579-z. Epub 2022 Sep 5.

Abstract

Parameters of the lipid metabolism and lipid peroxidation-antioxidant defense system in male adolescents with obesity, representatives of European and Mongoloid ethnicity were evaluated. Discriminant analysis revealed the most informative biochemical parameters for obese male adolescents: glutathione-S-transferase, VLDL cholesterol, glutathione peroxidase, reduced glutathione, and SOD activity for obese male Caucasian adolescents and glutathione-S-transferase, VLDL cholesterol, α-tocopherol, and glutathione peroxidase for Mongoloids obese male adolescents. The use of discriminant analysis allows implementing a differentiated ethnicity-oriented approach to prescribing antioxidant drugs in the complex therapy of obesity.

Keywords: antioxidant defense; ethnicity; obesity.

MeSH terms

  • Adolescent
  • Antioxidants* / metabolism
  • Cholesterol, VLDL
  • Discriminant Analysis
  • Ethnicity
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Humans
  • Lipid Peroxidation
  • Male
  • Obesity
  • Superoxide Dismutase / metabolism
  • Transferases / metabolism
  • alpha-Tocopherol*

Substances

  • Antioxidants
  • Cholesterol, VLDL
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Transferases
  • Glutathione
  • alpha-Tocopherol