A review on biofilms and the currently available antibiofilm approaches: Matrix-destabilizing hydrolases and anti-bacterial peptides as promising candidates for the food industries

Int J Biol Macromol. 2022 Oct 31:219:1163-1179. doi: 10.1016/j.ijbiomac.2022.08.192. Epub 2022 Sep 1.

Abstract

Biofilms are communities of microorganisms that can be harmful and/or beneficial, depending on location and cell content. Since in most cases (such as the formation of biofilms in laboratory/medicinal equipment, water pipes, high humidity-placed structures, and the food packaging machinery) these bacterial and fungal communities are troublesome, researchers in various fields are trying to find a promising strategy to destroy or slow down their formation. In general, anti-biofilm strategies are divided into the plant-based and non-plant categories, with the latter including nanoparticles, bacteriophages, enzymes, surfactants, active peptides and free fatty acids. In most cases, using a single strategy will not be sufficient to eliminate biofilm, and consequently, two or more strategies will inevitably be used to deal with this unwanted phenomenon. According to the analysis of potential biofilm inhibition strategies, the best option for the food industry would be the use of hydrolase enzymes and peptides extracted from natural sources. This article represents a systematic review of the previous efforts made in these directions.

Keywords: Antibiofilm strategies; Biofilms; Hydrolases; Non-herbal antibiofilms; Peptides; Plant-derived compounds.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteria
  • Biofilms
  • Fatty Acids, Nonesterified*
  • Food Industry
  • Hydrolases*
  • Peptides / pharmacology
  • Surface-Active Agents / pharmacology

Substances

  • Anti-Bacterial Agents
  • Fatty Acids, Nonesterified
  • Peptides
  • Surface-Active Agents
  • Hydrolases