Quantum dots: The cutting-edge nanotheranostics in brain cancer management

Pratik Chakraborty; Sabya Sachi Das; Abhijit Dey; Apala Chakraborty; Chiranjib Bhattacharyya; Ramesh Kandimalla; Biswajit Mukherjee; Abilash Valsala Gopalakrishnan; Sandeep Kumar Singh; Shubham Kant; Parma Nand; Shreesh Ojha; Pravir Kumar; Niraj Kumar Jha; Saurabh Kumar Jha; Saikat Dewanjee

doi:10.1016/j.jconrel.2022.08.047

Quantum dots: The cutting-edge nanotheranostics in brain cancer management

J Control Release. 2022 Oct:350:698-715. doi: 10.1016/j.jconrel.2022.08.047. Epub 2022 Sep 7.

Authors

Pratik Chakraborty¹, Sabya Sachi Das², Abhijit Dey³, Apala Chakraborty⁴, Chiranjib Bhattacharyya¹, Ramesh Kandimalla⁵, Biswajit Mukherjee⁴, Abilash Valsala Gopalakrishnan⁶, Sandeep Kumar Singh⁷, Shubham Kant⁸, Parma Nand⁸, Shreesh Ojha⁹, Pravir Kumar¹⁰, Niraj Kumar Jha¹¹, Saurabh Kumar Jha¹², Saikat Dewanjee¹³

Affiliations

¹ Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
² Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India; School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun 248009, Uttarakhand, India.
³ Pharmaceutics Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
⁴ Department of Life Sciences, Presidency University, Kolkata 700073, West Bengal, India.
⁵ Department of Biochemistry, Kakatiya Medical College, Warangal 506007, Telangana, India; Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Hyderabad 500007, India.
⁶ Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
⁷ Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.
⁸ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, UP 201310, India.
⁹ Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P.O. Box 15551, Abu Dhabi, United Arab Emirates.
¹⁰ Molecular Neuroscience and Functional Genomics Laboratory, Delhi Technological University (Formerly Delhi College of Engineering), Delhi, India.
¹¹ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, UP 201310, India. Electronic address: nirajkumarjha2011@gmail.com.
¹² Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, UP 201310, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India. Electronic address: saurabh.jha@sharda.ac.in.
¹³ Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: saikat.dewanjee@jadavpuruniversity.in.

PMID: 36057397
DOI: 10.1016/j.jconrel.2022.08.047

Abstract

Quantum dots (QDs) are semiconductor nanocrystals possessing unique optoelectrical properties in that they can emit light energy of specific tunable wavelengths when excited by photons. They are gaining attention nowadays owing to their all-around ability to allow high-quality bio-imaging along with targeted drug delivery. The most lethal central nervous system (CNS) disorders are brain cancers or malignant brain tumors. CNS is guarded by the blood-brain barrier which poses a selective blockade toward drug delivery into the brain. QDs have displayed strong potential to deliver therapeutic agents into the brain successfully. Their bio-imaging capability due to photoluminescence and specific targeting ability through the attachment of ligand biomolecules make them preferable clinical tools for coming times. Biocompatible QDs are emerging as nanotheranostic tools to identify/diagnose and selectively kill cancer cells. The current review focuses on QDs and associated nanoformulations as potential futuristic clinical aids in the continuous battle against brain cancer.

Keywords: Bio-imaging; Blood-brain barrier; Brain cancer; Nanotheranostics; Photodynamic therapy; Quantum dots.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms* / diagnostic imaging
Brain Neoplasms* / drug therapy
Drug Delivery Systems / methods
Humans
Ligands
Quantum Dots* / chemistry
Theranostic Nanomedicine

Substances

Ligands