Construction of ANbO3 (A= Na, K)/f-carbon nanofiber composite: Rapid and real-time electrochemical detection of hydroxychloroquine in environmental samples

Abstract

Hydroxychloroquine (HCQ) is a significant viral resistant drug widely acknowledged for its immunomodulatory and anti-inflammatory activities. To minimize the impact of HCQ residues on environmental pathways, exploring control measures is vital. In this regard, electrochemical sensing of HCQ using well-structured functional materials is advantageous. This work aims to provide an economical and sustainable route for the synthesis of ANbO₃ (A = Na,K) perovskites via a thymol-menthol-based natural deep eutectic solvent. The as-synthesized NaNbO₃ and KNbO₃ are pinned to functionalized carbon nanofibers (f-CNF) via an ultrasonication approach. Benefitting from the synergistic effect of rapid electron transfer and improved surface area, enhanced electrochemical activity for NaNbO₃@f-CNF/GCE is achieved. The fabricated NaNbO₃@f-CNF displays a LOD (DPV = 0.01 μM, i-t = 0.007 μM), wide dynamic range (DPV = 0.09-22.5 μM, i-t = 0.006-35 μM), outstanding selectivity, and reproducibility, proving feasible in real-time analysis with good recovery rates (±97.67-99.81%). The NADES-mediated preparation of perovskites evades the incorporation of traditional toxic solvents and yields atom-efficient ANbO₃ (A = Na,K) associated with green solvent templates. This validates the sustainable fabrication of electrode materials with reduced energy stipulations for detecting hazardous drug pollutants in the ecosystem.

Keywords: Analytical chemistry; Electrochemical sensor; Environmental pollutants; Green synthesis; Natural deep eutectic solvent.