Spatial Distribution and Assessment of the Human Health Risks of Heavy Metals in a Retired Pharmaceutical Industrial Area, Southwest China

Bull Environ Contam Toxicol. 2022 Nov;109(5):808-816. doi: 10.1007/s00128-022-03503-9. Epub 2022 Sep 3.

Abstract

Heavy metals pollution in pharmaceutical industries received increasing attention. A total of 94 soil samples were collected in this study. Results showed the mean contents of Hg, Cd, As, Pb, Ni and Cu were 0.21, 0.26, 9.59, 55.06, 51.52 and 50.81 mg·kg-1, respectively. The spatial distribution of metals in topsoil largely attributed to the pharmaceutical production process. The distribution of Hg and As were related to the production of medical absorbent cotton. While Ni was related to the fuel supply of Ni-rich coal. Cr, Cu and Pb mainly distributed in the process which they were used as catalysts. The vertical migration of metals was complex in soil. To a great extent, it was related to the texture of the soil and the properties of metals in this filed. The total non-cancer and cancer human health risk were within the limits of USEPA (10-6 a-1). This demonstrated the health risks of individual's exposure to heavy metals in this factory was acceptable.

Keywords: Heavy metal; Human health risks; Migration; Pharmaceutical industrial area; Spatial distribution.

MeSH terms

  • China
  • Environmental Monitoring / methods
  • Humans
  • Lead
  • Mercury*
  • Metals, Heavy* / analysis
  • Pharmaceutical Preparations
  • Risk Assessment
  • Soil
  • Soil Pollutants* / analysis

Substances

  • Soil Pollutants
  • Lead
  • Metals, Heavy
  • Soil
  • Mercury
  • Pharmaceutical Preparations