Genomic and epidemiologic surveillance of SARS-CoV-2 in Southern Brazil and identification of a new Omicron-L452R sublineage

Virus Res. 2022 Nov:321:198907. doi: 10.1016/j.virusres.2022.198907. Epub 2022 Aug 30.

Abstract

Recently, SARS-CoV-2 Omicron variant (B.1.1.529) was first identified in Botswana in November 2021. In a short period of time, this highly mutated variant replaced the previous dominant Delta variant, causing an exponential increase in the number of COVID-19 cases, resulting in a new wave of pandemic. This current research article aims to analyze and summarize information about the genetic characteristics, amino acid mutations and epidemiological data providing scientific findings to enrich the SARS-CoV-2 knowledge. More importantly, we describe here, for the first time, the identification of a new Omicron variant of concern: Omicron-L452R in Brazil.

Keywords: Mutational scanning; S:L452R; SARS-CoV-2; VOC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids
  • Brazil / epidemiology
  • COVID-19* / epidemiology
  • Epidemiological Monitoring
  • Genomics
  • Humans
  • SARS-CoV-2* / genetics

Substances

  • Amino Acids

Supplementary concepts

  • SARS-CoV-2 variants