CD36 favours fat sensing and transport to govern lipid metabolism

Prog Lipid Res. 2022 Nov:88:101193. doi: 10.1016/j.plipres.2022.101193. Epub 2022 Aug 31.

Abstract

CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 and lipid dysmetabolism and obesity has been identified in various models and human studies. Nevertheless, the mechanisms by which CD36 regulates lipid metabolism and the role of CD36 in metabolic diseases remain obscure. Here, we summarize the latest research on the role of membrane CD36 in fat metabolism, with emphasis on CD36-mediated fat sensing and transport. This review also critically discusses the factors affecting the regulation of CD36-mediated fat dysfunction. Finally, we review previous clinical evidence of CD36 in metabolic diseases and consider the path forward.

Keywords: CD36; Fatty acids; Lipid dysmetabolism; Lipid sensing; Lipid transport; Obesity.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD36 Antigens* / metabolism
  • Dietary Fats
  • Fatty Acids / metabolism
  • Humans
  • Lipid Metabolism* / physiology
  • Obesity / metabolism

Substances

  • CD36 Antigens
  • Fatty Acids
  • Dietary Fats