Physical activity and the risk of non-Hodgkin lymphoma subtypes: A pooled analysis

Terry Boyle; Geffen Kleinstern; Paige M Bracci; James R Cerhan; Yolanda Benavente; Delphine Casabonne; Brian C-H Chiu; Thomas M Habermann; Elizabeth A Holly; Mark Liebow; Aaron Norman; Ora Paltiel; Dennis Robinson; Nathaniel Rothman; Rania Abu Seir; Susan L Slager; Paul J Villeneuve; Sophia S Wang; Dennis D Weisenburger; John J Spinelli

doi:10.1002/ijc.34266

Physical activity and the risk of non-Hodgkin lymphoma subtypes: A pooled analysis

Int J Cancer. 2023 Feb 1;152(3):396-407. doi: 10.1002/ijc.34266. Epub 2022 Sep 8.

Authors

Terry Boyle^{1

2

3}, Geffen Kleinstern⁴, Paige M Bracci⁵, James R Cerhan⁶, Yolanda Benavente^{7

8}, Delphine Casabonne^{7

8}, Brian C-H Chiu⁹, Thomas M Habermann¹⁰, Elizabeth A Holly⁵, Mark Liebow¹⁰, Aaron Norman⁶, Ora Paltiel^{11

12}, Dennis Robinson⁶, Nathaniel Rothman¹³, Rania Abu Seir¹⁴, Susan L Slager⁶, Paul J Villeneuve¹⁵, Sophia S Wang¹⁶, Dennis D Weisenburger¹⁷, John J Spinelli²

Affiliations

¹ Australian Centre for Precision Health, Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
² Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
³ School of Public Health, Curtin University, Perth, Western Australia, Australia.
⁴ School of Public Health, University of Haifa, Haifa, Israel.
⁵ Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
⁶ Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
⁷ Unit of Molecular and Genetic Epidemiology in Infections and Cancer (UNIC-Molecular), Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, Hospitalet De Llobregat, Spain.
⁸ Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP, Madrid, Spain.
⁹ Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
¹⁰ Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
¹¹ Braun School of Public Health and Community Medicine, Hadassah-Hebrew University, Jerusalem, Israel.
¹² Department of Hematology, Hadassah-Hebrew University, Jerusalem, Israel.
¹³ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
¹⁴ Department of Medical Laboratory Sciences, Faculty of Health Professions, Al-Quds University, Palestine.
¹⁵ School of Mathematics and Statistics and Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
¹⁶ Department of Health Analytics, Division of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, California, USA.
¹⁷ Department of Pathology, City of Hope National Medical Center, Duarte, California, USA.

PMID: 36054546
DOI: 10.1002/ijc.34266

Abstract

Non-Hodgkin lymphoma (NHL) is composed of a heterogeneous collection of subtypes with considerable differences in genetics, biology and aetiology. Studies to date on physical activity and NHL risk have not had sufficient sample size to evaluate whether associations differ by subtype. We pooled data from nine case-control studies to examine the association between moderate-to-vigorous intensity physical activity (MVPA) and risk of NHL overall and by subtype (diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukaemia/small lymphocytic lymphoma, marginal zone lymphoma and mature T-cell lymphoma). A total of 5653 cases and 9115 controls were included in the pooled analysis. Physical activity was harmonised across nine studies and modelled as study-specific tertiles. Multinomial logistic regression was used to estimate the association between physical activity and NHL, adjusting for confounders. The overall odds of NHL was 13% lower among participants in the most active tertile of MVPA compared to the least active tertile (adjusted odds ratio = 0.87, 95% CI = 0.80, 0.95). Similar decreases were observed across NHL subtypes. In summary, in this pooled analysis of case-control studies, physical activity was associated with a modest risk reduction for each NHL subtype examined and with overall NHL.

Keywords: epidemiology; non-Hodgkin lymphoma; physical activity.

Publication types

Meta-Analysis
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, P.H.S.
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Exercise
Humans
Lymphoma, Follicular* / epidemiology
Lymphoma, Follicular* / etiology
Lymphoma, Non-Hodgkin* / complications
Lymphoma, Non-Hodgkin* / etiology
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding