Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae

Zoe Swank; Yasmeen Senussi; Zachary Manickas-Hill; Xu G Yu; Jonathan Z Li; Galit Alter; David R Walt

doi:10.1093/cid/ciac722

Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae

Clin Infect Dis. 2023 Feb 8;76(3):e487-e490. doi: 10.1093/cid/ciac722.

Authors

Zoe Swank^{1

2

3}, Yasmeen Senussi^{1

2

3}, Zachary Manickas-Hill⁴, Xu G Yu^{1

4

5}, Jonathan Z Li^{1

5}, Galit Alter^{4

6}, David R Walt^{1

2

3}

Affiliations

¹ Harvard Medical School, Boston, Massachusetts, USA.
² Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
³ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
⁴ Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
⁵ Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁶ Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.

Keywords: COVID-19; SARS-CoV-2 antigens; long COVID; post-acute sequelae of COVID-19 (PASC); spike.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Viral* / blood
Antigens, Viral* / immunology
Biomarkers / blood
COVID-19* / blood
COVID-19* / complications
COVID-19* / immunology
Disease Progression
Humans
Post-Acute COVID-19 Syndrome* / blood
Post-Acute COVID-19 Syndrome* / diagnosis
Post-Acute COVID-19 Syndrome* / immunology
SARS-CoV-2*
Spike Glycoprotein, Coronavirus* / blood

Substances

Antigens, Viral
Biomarkers
spike protein, SARS-CoV-2
Spike Glycoprotein, Coronavirus

Grants and funding

NIH