Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome

Vito Romano; Davide Romano; Paolo Semeraro; Eliana Forbice; Antonio Iaria; Teodoro Pizzolante; Micol Frassi; Franco Franceschini; Francesco Semeraro

doi:10.1016/j.ajoc.2022.101685

Therapeutic Hyper-CL soft contact lens in Sjögren's syndrome

Am J Ophthalmol Case Rep. 2022 Aug 19:28:101685. doi: 10.1016/j.ajoc.2022.101685. eCollection 2022 Dec.

Authors

Vito Romano¹, Davide Romano¹, Paolo Semeraro², Eliana Forbice¹, Antonio Iaria¹, Teodoro Pizzolante¹, Micol Frassi², Franco Franceschini², Francesco Semeraro¹

Affiliations

¹ Eye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
² Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Abstract

Purpose: To report increased corneal bioavailability of allogenic serum when used in combinations with Therapeutic Hyper-CL™ soft contact lens in a patient with severe Sjögren's syndrome-associated dry eye.

Observations: A 57-year-old woman with a medical history of bilateral severe Sjögren's syndrome-associated dry eye and previous amniotic membrane patch for autoimmune corneal perforation in her left eye was referred for left eye recurrence of progressive melting and pending perforation. After manual corneal trephination, full thickness transplant and sutured amniotic membrane patch, a Therapeutic Hyper-CL™ soft contact lens (EyeYon Medical, Ness Tziona, Israel) was fit. The patient was commenced in the left eye with topical corticosteroid, antibiotic, and allogenic serum eye drops. In the right eye the patient had silicone hydrogel bandage contact lens and was under same treatment of the left eye for previous endothelial keratoplasty. In order to evaluate the efficacy and increased corneal availability of drugs provided by Therapeutic Hyper-CL™ compared with silicone hydrogel soft contact lens, anterior segment OCT was performed.

Conclusions and importance: The anterior segment OCT showed a thicker meniscus of fluid and possibly subsequent increase of trophic factors bioavailability in left eye compared with right eye. Therefore, in case of severe and refractory dry-eye disease the combination of Therapeutic Hyper-CL™ and serum eye drops may be representing a valid therapeutic approach.

Keywords: AM, amniotic membrane; Cornea; Hyper-cl; SS, Sjögren's syndrome; Serum eye; Sjogren; allo-SED, allogenic serum eye drops; auto-SED, autologous serum eye drops; dry eye.

Publication types

Case Reports