Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma

Viktor Proesmans; Tom Vandaele; Jan Van Slambrouck; Albert Wolthuis; André D Hoore; Jeroen Dekervel; Eric Van Cutsem; Raphaëla Dresen; Gert De Hertogh; Karlien Degezelle; Dirk Van Raemdonck; Philippe Nafteux; Laurens J Ceulemans

doi:10.1080/02656736.2022.2104938

Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma

Int J Hyperthermia. 2022;39(1):1153-1157. doi: 10.1080/02656736.2022.2104938.

Authors

Viktor Proesmans¹, Tom Vandaele¹, Jan Van Slambrouck^{1

2}, Albert Wolthuis^{3

4}, André D Hoore^{3

4}, Jeroen Dekervel^{5

6}, Eric Van Cutsem^{5

6}, Raphaëla Dresen^{7

8}, Gert De Hertogh^{8

9}, Karlien Degezelle¹⁰, Dirk Van Raemdonck^{1

2}, Philippe Nafteux^{1

2}, Laurens J Ceulemans^{1

2}

Affiliations

¹ Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
² Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.
³ Department of Abdominal Surgery, University Hospitals Leuven, Leuven, Belgium.
⁴ Department of Oncology, laboratory of Abdominal Surgical Oncology, KU Leuven, Leuven, Belgium.
⁵ Department of Gastro-Enterology, University Hospitals Leuven, Leuven, Belgium.
⁶ Department of Oncology, Laboratory of Clinical Digestive Oncology, KU Leuven, Leuven, Belgium.
⁷ Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
⁸ Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
⁹ Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
¹⁰ Department of Cardiac Surgery, Division Perfusion, University Hospitals Leuven, Leuven, Belgium.

PMID: 36049823
DOI: 10.1080/02656736.2022.2104938

Abstract

Aim: Pleural dissemination of pseudomyxoma peritonei (PMP) is an extremely rare diagnosis, for which no standard therapy is available.Methods: We describe the successful treatment of a 67-year-old male diagnosed with left-sided intrapleural dissemination of PMP (low-grade appendiceal mucinous neoplasm), 2 years after treatment of abdominal PMP with cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy. Treatment consisted of extended pleural decortication (ePD) and oxaliplatin-based hyperthermic intrathoracic chemotherapy (HITHOC). The patient is doing well without complications or signs of recurrence, 26 months after thoracic surgery.Conclusion: ePD in combination with HITHOC is a valuable treatment for thoracic PMP.

Keywords: HITHOC; pleural decortication; pseudomyxoma peritonei.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Appendiceal Neoplasms* / therapy
Combined Modality Therapy
Cytoreduction Surgical Procedures
Humans
Hyperthermia, Induced*
Male
Peritoneal Neoplasms* / diagnostic imaging
Peritoneal Neoplasms* / drug therapy
Peritoneal Neoplasms* / surgery
Pseudomyxoma Peritonei* / diagnostic imaging
Pseudomyxoma Peritonei* / drug therapy
Pseudomyxoma Peritonei* / surgery
Retrospective Studies