Recent advances in HDAC-targeted imaging probes for cancer detection

Chu Tang; Xinan Wang; Yushen Jin; Fu Wang

doi:10.1016/j.bbcan.2022.188788

Recent advances in HDAC-targeted imaging probes for cancer detection

Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188788. doi: 10.1016/j.bbcan.2022.188788. Epub 2022 Aug 30.

Authors

Chu Tang¹, Xinan Wang², Yushen Jin³, Fu Wang⁴

Affiliations

¹ Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; Xianyang Key Laboratory of Molecular Imaging and Drug Synthesis, School of Pharmacy, School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xianyang 712046, Shaanxi, China.
² Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China.
³ Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
⁴ Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; Xianyang Key Laboratory of Molecular Imaging and Drug Synthesis, School of Pharmacy, School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xianyang 712046, Shaanxi, China; Institute of Medical Engineering, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: wangfu@xjtu.edu.cn.

PMID: 36049581
DOI: 10.1016/j.bbcan.2022.188788

Abstract

Histone Deacetylases (HDACs) are abnormally high expressed in various cancers and play a crucial role in regulating gene expression. While HDAC-targeted inhibitors have been rapidly developed and approved in the last twenty years, noninvasive monitoring and visualizing the expression levels of HDACs in tumor tissues might help to early diagnosis in cancer and predict the response to HDAC-targeted cancer therapy. In this review, we summarize the recent advancements in the development of HDAC-targeted probes and their applications in cancer imaging and image-guided surgery. We also discuss the design strategies, advantages and disadvantages of these probes. We hope that this review will provide guidance for the design of HDAC-targeted imaging probes and clinical applications in future.

Keywords: HDACs; Noninvasive imaging; Probes; Tumor diagnosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Histone Deacetylase Inhibitors / metabolism
Histone Deacetylase Inhibitors / pharmacology
Histone Deacetylase Inhibitors / therapeutic use
Histone Deacetylases* / genetics
Histone Deacetylases* / metabolism
Histone Deacetylases* / therapeutic use
Humans
Neoplasms* / diagnostic imaging
Neoplasms* / drug therapy
Neoplasms* / genetics

Substances

Histone Deacetylase Inhibitors
Histone Deacetylases