Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes

Jiming Zhang; Zheng Wang; Yiming Dai; Lei Zhang; Jianqiu Guo; Shenliang Lv; Xiaojuan Qi; Dasheng Lu; Weijiu Liang; Yang Cao; Chunhua Wu; Xiuli Chang; Zhijun Zhou

doi:10.1016/j.envres.2022.114226

Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes

Environ Res. 2022 Dec;215(Pt 1):114226. doi: 10.1016/j.envres.2022.114226. Epub 2022 Aug 30.

Authors

Jiming Zhang¹, Zheng Wang², Yiming Dai³, Lei Zhang⁴, Jianqiu Guo⁵, Shenliang Lv⁶, Xiaojuan Qi⁷, Dasheng Lu⁸, Weijiu Liang⁹, Yang Cao¹⁰, Chunhua Wu¹¹, Xiuli Chang¹², Zhijun Zhou¹³

Affiliations

¹ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: zhangjiming@fudan.edu.cn.
² School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: 20211020149@fudan.edu.cn.
³ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: 20111020031@fudan.edu.cn.
⁴ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: 19211020054@fudan.edu.cn.
⁵ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: jqguo14@fudan.edu.cn.
⁶ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: 12211020014@fudan.edu.cn.
⁷ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China; Zhejiang Provincial Center for Disease Control and Prevention, No.3399 Binsheng Road, Hangzhou, 310051, China. Electronic address: xjqi@cdc.zj.cn.
⁸ Shanghai Center for Disease Control and Prevention, No.1380 West Zhongshan Road, Shanghai, 200336, China. Electronic address: ludasheng@scdc.cn.
⁹ Changning Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, 200051, China. Electronic address: wj8501@aliyun.com.
¹⁰ Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, 70182, Sweden; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden. Electronic address: yang.cao@oru.se.
¹¹ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: chwu@fudan.edu.cn.
¹² School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: xlchang@fudan.edu.cn.
¹³ School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: zjzhou@fudan.edu.cn.

PMID: 36049513
DOI: 10.1016/j.envres.2022.114226

Abstract

Background: Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear.

Objective: To explore the association between prenatal triclosan exposure and birth outcomes.

Methods: Based on 726 mother-child pairs from the Sheyang Mini Birth Cohort Study (SMBCS), we used the available (published) data of triclosan in maternal urines, the hormones including thyroid-related hormones, gonadal hormones in cord blood, and adipokines, trimethylamine-N-oxide (TMAO) and its precursors in cord blood to explore possible health effects of triclosan on birth outcomes through assessing different hormones and parameters, using Bayesian mediation analysis.

Results: Maternal triclosan exposure was associated with ponderal index (β = 0.317) and head circumference (β = -0.172) in generalized linear models. In Bayesian mediation analysis of PI model, estradiol (β = 0.806) and trimethylamine (TMA, β = 0.164) showed positive mediation effects, while total thyroxine (TT4, β = -0.302), leptin (β = -2.023) and TMAO (β = -0.110) showed negative mediation effects. As for model of head circumference, positive mediation effects were observed in free thyroxine (FT4, β = 0.493), TMA (β = 0.178), and TMAO (β = 0.683), negative mediation effects were observed in TT4 (β = -0.231), testosterone (β = -0.331), estradiol (β = -1.153), leptin (β = -2.361), choline (β = -0.169), betaine (β = -0.104), acetyl-L-carnitine (β = -0.773).

Conclusion: The results indicated triclosan can affect intrauterine growth by interfering thyroid-related hormones, gonadal hormones, adipokines, TMAO and its precursors.

Keywords: Bayesian mediation analysis; Birth outcome; Endocrine disruptor; Mediation effect; Triclosan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcarnitine
Bayes Theorem
Betaine
Choline
Cohort Studies
Estradiol
Female
Humans
Leptin
Maternal Exposure / adverse effects
Methylamines
Oxides
Pregnancy
Testosterone
Thyroid Hormones
Thyroxine
Triclosan* / toxicity

Substances

Leptin
Methylamines
Oxides
Thyroid Hormones
Betaine
Testosterone
Triclosan
Estradiol
Acetylcarnitine
trimethyloxamine
trimethylamine
Choline
Thyroxine