Enzyme-catalyzed allylic oxidation reactions: A mini-review

Maoyao Wang; Xiaojian Zhou; Zhongqiang Wang; Yongzheng Chen

doi:10.3389/fchem.2022.950149

Enzyme-catalyzed allylic oxidation reactions: A mini-review

Front Chem. 2022 Aug 15:10:950149. doi: 10.3389/fchem.2022.950149. eCollection 2022.

Authors

Maoyao Wang^{1

2}, Xiaojian Zhou^{1

2}, Zhongqiang Wang^{1

2}, Yongzheng Chen^{1

2}

Affiliations

¹ Key Laboratory of Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, Zunyi Medical University, Zunyi, China.
² Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.

Abstract

Chiral allylic oxidized products play an increasingly important role in the pharmaceutical, agrochemical, and pharmaceutical industries. Biocatalytic C-H oxyfunctionalization to synthesize allylic oxidized products has attracted great attention in recent years, with the ability to simplify synthetic approaches toward complex compounds. As a result, scientists have found some new enzymes and mutants through techniques of gene mining and enzyme-directed evolution in recent years. This review summarizes the recent developments in biocatalytic selective oxidation of olefins by different kinds of biocatalysts.

Keywords: C–H activation; P450; UPO; allylic oxidation; biocatalysis; oxyfunctionalization.

Publication types

Review