Cryo-Biopsy versus 19G needle versus 22G needle with EBUS-TBNA endoscopy

Rena Oikonomidou; Dimitris Petridis; Christoforos Kosmidis; Konstantinos Sapalidis; Wolfgang Hohenforst-Schmidt; Vagelis Christakidis; Savas Petanidis; Dimitris Mathaios; Eleni Isidora Perdikouri; Sofia Baka; Christos Tolis; Anastasios Vagionas; Bojan Zaric; Aris Ioannidis; Marios Anemoulis; Konstantinos Porpodis; Vasileios Papadopoulos; Paul Zarogoulidis

doi:10.7150/jca.75589

Cryo-Biopsy versus 19G needle versus 22G needle with EBUS-TBNA endoscopy

J Cancer. 2022 Aug 8;13(10):3084-3090. doi: 10.7150/jca.75589. eCollection 2022.

Authors

Rena Oikonomidou¹, Dimitris Petridis², Christoforos Kosmidis¹, Konstantinos Sapalidis¹, Wolfgang Hohenforst-Schmidt³, Vagelis Christakidis⁴, Savas Petanidis⁵, Dimitris Mathaios⁶, Eleni Isidora Perdikouri⁷, Sofia Baka⁸, Christos Tolis⁹, Anastasios Vagionas¹⁰, Bojan Zaric¹¹, Aris Ioannidis¹², Marios Anemoulis¹³, Konstantinos Porpodis¹⁴, Vasileios Papadopoulos¹⁵, Paul Zarogoulidis¹⁶

Affiliations

¹ Health Center of Evosmos, Thessaloniki, Greece.
² Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, Thessaloniki, Greece.
³ Sana Clinic Group Franken, Department of Cardiology / Pulmonology / Intensive Care / Nephrology, ''Hof'' Clinics, University of Erlangen, Hof, Germany.
⁴ Oncology Department, General Hospital of Serres, Serres, Greece.
⁵ Department of Pulmonology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
⁶ Oncology Department, General Hospital of Rhodes, Rhodes, Greece.
⁷ Oncology Department, General Hospital of Volos, Greece.
⁸ Oncology Department, "Interbalkan" European Medical Center, Thessaloniki, Greece.
⁹ Oncoderm, Private Oncology Clinic, Ioannina, Greece.
¹⁰ Oncology Department, General Hospital of Kavala, Kavala, Greece.
¹¹ Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia.
¹² Surgery Department, Genesis Private Hospital, Thessaloniki, Greece.
¹³ General Surgery Department, General Clinic Euromedica, Thessaloniki, Greece.
¹⁴ Pulmonary Department, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹⁵ Oncology Department, University General Hospital of Larissa, University of Thessali, Larissa, Greece.
¹⁶ Pulmonary-Oncology Department, "General Clinic" Private Clinic, Thessaloniki, Greece.

Abstract

Introduction: We have been using cryo-biopsy for endobronchial lesions for lung cancer diagnosis and debulking. Cryo-biopsy is also known to be an excellent tool for diagnosis of lung interstitial disease. Recently cryo-biopsy with the 1.1mm probe was used for lymphnode biopsy. Patients and Methods: 311 patients participated with lymphadenopathy and at least one lung lesion. The following tools were used for diagnosis; 22G Mediglobe Sonotip, 22G Medigolbe, 21G Olympus, 19G Olympus and 1.1mm cryo probe ERBE CRYO 2 system (3 seconds froze). A PENTAX Convex-probe EBUS was used for biopsy guidance. Results: Cell-blocks slices had a higher number in the 19G needle group (19G> Cryo Probe>22G Mediglobe Sonotip >21G Olympus >22G Mediglobe). Conclusion: Cryo biopsy of the lymphnodes is safe with the 1.1mm cryo probe. Further studies are needed in order to evaluate new probes and the technique specifications.

Keywords: 19G needle; 21G needle; 22G needle; Linear-EBUS; bronchoscopy; cancer; cryo-biopsy; lung cancer; radial-ebus.