The Association Between Medication Non-Adherence and Early and Late Readmission Rates for Patients with Acute Coronary Syndrome

Hussam Murad; Mohammed Basheikh; Mohamed Zayed; Roaa Albeladi; Yousef Alsayed

doi:10.2147/IJGM.S376926

The Association Between Medication Non-Adherence and Early and Late Readmission Rates for Patients with Acute Coronary Syndrome

Int J Gen Med. 2022 Aug 25:15:6791-6799. doi: 10.2147/IJGM.S376926. eCollection 2022.

Authors

Hussam Murad^{1

2}, Mohammed Basheikh³, Mohamed Zayed^{4

5}, Roaa Albeladi⁶, Yousef Alsayed⁶

Affiliations

¹ Department of Pharmacology, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
² Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
³ Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
⁴ Department of Physiology, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
⁵ Department of Physiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
⁶ Medical Students, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.

Abstract

Purpose: Unplanned hospital readmission forms costly, but preventable burdens on healthcare system. This study was designed to evaluate cardiovascular-related readmission rate after discharge of acute coronary syndrome (ACS) patients and its relationship with medication adherence at a university hospital, Saudi Arabia.

Methods: A total of 370 consecutive patients presenting with ACS were involved. The inclusion criteria were clinical and coronary angiography diagnostic data of ACS. Exclusion criteria included heart valve disease, myocarditis, hepatic disease, and history of acute infection during the previous two weeks. Patients were divided into index admission group (n = 291) and unplanned readmission group (n = 79). Readmission and medication adherence rates were evaluated during 1-30, 31-180, 181-365, and 366-548 days post-ACS discharge. Medication adherence was estimated with a (yes/no) questionnaire.

Results: The overall readmission rate was 21.4%; individual rates were 30.4%, 38.0%, 27.8%, and 3.8% and the overall medication adherence rate was 62.03%, while individual rates were 54.2%, 70.0%, 63.6%, and 33.3% during the four periods, respectively. There were strong correlations between medication non-adherence and readmission rates. Heart failure, ST-elevated myocardial infarction, unstable angina, cerebrovascular accident, and arrhythmia represented the top causes. Body mass index was higher in readmission group. There were significant correlations between smoking, hypertension, cerebrovascular accident, ischemic heart disease, previous stent, instent restenosis, and LDL-cholesterol as predictor factors and readmission rate.

Conclusion: The cardiovascular-related unplanned readmission rate post-ACS discharge was 21.4%, and medication non-adherence rate was 37.97%. There were strong correlations between them in the time frames from 1-month to 1.5-year post-discharge. The individual rates decreased by time, but the first month showed lower rates than the following 5 months and this indicated the role of factors other than medication non-adherence in readmission. The rates are generally consistent with the international levels but utilizing technology can further improve medication adherence and reduce readmission rates.

Keywords: Saudi Arabia; acute coronary syndrome; medication adherence; readmission rate.