Emerging roles of long non-coding RNAs in keloids

Xin Yu; Xueqing Zhu; Hongjun Xu; Linfeng Li

doi:10.3389/fcell.2022.963524

Emerging roles of long non-coding RNAs in keloids

Front Cell Dev Biol. 2022 Aug 15:10:963524. doi: 10.3389/fcell.2022.963524. eCollection 2022.

Authors

Xin Yu¹, Xueqing Zhu¹, Hongjun Xu¹, Linfeng Li¹

Affiliation

¹ Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Abstract

Keloids are pathologic wound healing conditions caused by fibroblast hyperproliferation and excess collagen deposition following skin injury or irritation, which significantly impact patients by causing psychosocial and functional distress. Extracellular matrix (ECM) deposition and human fibroblast proliferation represents the main pathophysiology of keloid. Long non-coding RNAs (LncRNAs) play important roles in many biological and pathological processes, including development, differentiation and carcinogenesis. Recently, accumulating evidences have demonstrated that deregulated lncRNAs contribute to keloids formation. The present review summarizes the researches of deregulated lncRNAs in keloid. Exploring lncRNA-based methods hold promise as new effective therapies against keloid.

Keywords: H19; HOXA11-AS; Smad5 protein; keloids; long non-coding RNAs.

Publication types

Review