The Roles and Regulation of Ferroptosis in Cancer Progression

Yu Yang; Te Ma; Ting Hu; Chengcheng Ma; Huiqing Tu; Shunqin Zhu

doi:10.2174/1386207325666220831151036

The Roles and Regulation of Ferroptosis in Cancer Progression

Comb Chem High Throughput Screen. 2023;26(6):1141-1148. doi: 10.2174/1386207325666220831151036.

Authors

Yu Yang^{1

2}, Te Ma^{1

2}, Ting Hu¹, Chengcheng Ma¹, Huiqing Tu¹, Shunqin Zhu¹

Affiliations

¹ School of Life Sciences, Southwest University, Beibei, Chongqing, 400716, China.
² High School Affiliated to Southwest University, Chongqing 400715, China.

PMID: 36045533
DOI: 10.2174/1386207325666220831151036

Abstract

Ferroptosis is an iron-dependent, nonapoptotic form of regulatory death and has received extensive attention. Fenton reaction related to iron metabolism release high levels of Reactive Oxygen Species (ROS), and the intracellular ROS content is closely related to various diseases; the iron ion concentration in many diseased cells is also disordered. In this paper, the advances in ferroptosis research are summarized, and the regulatory mechanisms of ferroptosis, including inducers and regulatory protein of ferroptosis in cancer progression. We expect that this study will benefit the further development of basic research and clinical application of ferroptosis for cancer treatment.

Keywords: Ferroptosis; GPX4; ROS; cancer progression; cell death; system Xc-.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ferroptosis*
Humans
Iron / metabolism
Iron / therapeutic use
Neoplasms* / drug therapy
Neoplasms* / metabolism
Reactive Oxygen Species / metabolism

Substances

Reactive Oxygen Species
Iron