Abstract
We performed whole genome sequencing on SARS-CoV-2 from 59 vaccinated individuals from southwest Pennsylvania who tested positive between February and September, 2021. A comparison of mutations among vaccine breakthrough cases to a time-matched control group identified potential adaptive responses of SARS-CoV-2 to vaccination.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral
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COVID-19* / epidemiology
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COVID-19* / prevention & control
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Genomics
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Humans
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Pennsylvania / epidemiology
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SARS-CoV-2 / genetics
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Viral Vaccines*
Substances
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Antibodies, Viral
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Viral Vaccines
Grants and funding
This work was supported by the University of Pittsburgh Medical Center (UPMC). UPMC had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Kady D. Waggle, Tung Phan, Alan Wells, Graham M. Snyder, Lee H. Harrison and Jane W. Marsh receive salary support from UPMC.