Genomic characterization of SARS-CoV-2 from vaccine breakthrough cases in Allegheny County, Pennsylvania

PLoS One. 2022 Aug 31;17(8):e0272954. doi: 10.1371/journal.pone.0272954. eCollection 2022.

Abstract

We performed whole genome sequencing on SARS-CoV-2 from 59 vaccinated individuals from southwest Pennsylvania who tested positive between February and September, 2021. A comparison of mutations among vaccine breakthrough cases to a time-matched control group identified potential adaptive responses of SARS-CoV-2 to vaccination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral
  • COVID-19* / epidemiology
  • COVID-19* / prevention & control
  • Genomics
  • Humans
  • Pennsylvania / epidemiology
  • SARS-CoV-2 / genetics
  • Viral Vaccines*

Substances

  • Antibodies, Viral
  • Viral Vaccines

Grants and funding

This work was supported by the University of Pittsburgh Medical Center (UPMC). UPMC had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Kady D. Waggle, Tung Phan, Alan Wells, Graham M. Snyder, Lee H. Harrison and Jane W. Marsh receive salary support from UPMC.