Advances in Metal-Organic Framework (MOFs) based biosensors for diagnosis: An update

Ghazala Ashraf; Tauqir Ahmad; Muhammad Zeeshan Ahmed; Murtaza; Yousef Rasimi

doi:10.2174/1568026622666220829125548

Advances in Metal-Organic Framework (MOFs) based biosensors for diagnosis: An update

Curr Top Med Chem. 2022 Aug 29. doi: 10.2174/1568026622666220829125548. Online ahead of print.

Authors

Ghazala Ashraf¹, Tauqir Ahmad², Muhammad Zeeshan Ahmed³, Murtaza⁴, Yousef Rasimi^{5

6}

Affiliations

¹ Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan Hubei, P. R. China.
² Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.
³ Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan.
⁴ Department of Chemical Sciences, University of Lakki Marwat, Khyber Pakhtunkhwa, Pakistan.
⁵ Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
⁶ Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

PMID: 36043769
DOI: 10.2174/1568026622666220829125548

Abstract

Metal-organic frameworks (MOFs) have significant advantages over other candidate classes of chemo-sensory materials owing to their extraordinary structural tunability and characteristics. MOF-based biosensing is a simple, and convenient method for identifying various species. Biomarkers are molecular or cellular processes that link environmental exposure to a health outcome. Biomarkers are important in understanding the links between environmental chemical exposure and the development of chronic diseases, as well as in identifying disease-prone subgroups. Until now, several species, including nanoparticles (NPs) and their nanocomposites, small molecules, and unique complex systems, have been used for the chemical sensing of biomarkers. Following the overview of the field, we discussed the various fabrication methods for MOFs development in this review. We provide a thorough overview of the previous five years of progress to broaden the scope of analytes for future research. Several enzymatic and non-enzymatic sensors are offered, together with a mandatory measuring method that includes detection range and dynamic range. In addition, we reviewed the comparison of enzymatic and non-enzymatic biosensors, inventive edges, and the difficulties that need to be solved. This work might open up new possibilities for material production, sensor development, medical diagnostics, and other sensing fields.

Keywords: Metal-organic frameworks; biomarkers; disease diagnosis.; dopamine; metabolites; protein.