Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous functions. The biophysical properties of the stratum corneum reflect the status of both epidermal function and systemic conditions. Type 2 diabetes in both murine models and humans displays alterations in epidermal functions, including reduced levels of stratum corneum hydration and increased epidermal permeability as well as delayed permeability barrier recovery, which can all provoke and exacerbate cutaneous inflammation. Because inflammation plays a pathogenic role in type 2 diabetes, a therapy that improves epidermal functions could be an alternative approach to mitigating type 2 diabetes and its associated cutaneous disorders.
表皮功能受到多种外源性和内源性因素的调节，包括年龄、心理应激、某些皮肤病、紫外线照射和污染，而表皮本身也可以调节皮肤和皮外的功能。角质层的生物和物理性质反映了表皮功能和全身状况。在小鼠模型和人类中，2型糖尿病都表现出表皮功能的变化，包括角质层水合作用水平降低、表皮渗透性增加、以及通透性屏障恢复延迟，这些都可以引发和加剧皮肤炎症。由于炎症在2型糖尿病中起致病作用，因此改善表皮功能的治疗可能是缓解2型糖尿病及其相关皮肤疾病的替代方法。.
Keywords: aging; cytokines; diabetes; keratinocytes; permeability barrier; stratum corneum hydration; 糖尿病; 细胞因子; 衰老; 角质层水化作用。; 角质形成细胞; 通透性屏障.
Published 2022. This article is a U.S. Government work and is in the public domain in the USA. Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.