The sun, cholesterol and Orai1 conspire in melanoma

Woo Young Chung; Shmuel Muallem

doi:10.15252/embj.2022112250

The sun, cholesterol and Orai1 conspire in melanoma

EMBO J. 2022 Oct 4;41(19):e112250. doi: 10.15252/embj.2022112250. Epub 2022 Aug 31.

Authors

Woo Young Chung¹, Shmuel Muallem¹

Affiliation

¹ Epithelial Signaling and Transport Section, National Institute of Dental Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Abstract

How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca²⁺ influx by Orai1, causing protein O-GlcNAcylation that promotes transformation to invasive melanoma.

Published 2022. This article is a U.S. Government work and is in the public domain in the USA.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural

MeSH terms

Calcium / metabolism
Cholesterol
Humans
Melanoma* / metabolism
ORAI1 Protein / genetics
ORAI1 Protein / metabolism
Skin Neoplasms* / etiology
Ultraviolet Rays

Substances

ORAI1 Protein
ORAI1 protein, human
Cholesterol
Calcium