Individualized pharmaceutical care for a patient after pancreaticoduodenectomy with trypsin replacement nutritional therapy: A case report

Medicine (Baltimore). 2022 Aug 26;101(34):e30209. doi: 10.1097/MD.0000000000030209.

Abstract

Rationale: Optimal nutritional therapy for pancreaticoduodenectomy (PD) has been debated; however, little is known about key points of pancreatin enteric-coated capsule administration, a critical component of the PD treatment regimen. Patients often report elevations in tablet platoon and steatorrhea, and steatorrhea may adversely affect nutritional therapy for PD. Herein, we report a case of individualized pharmaceutical care for a patient after PD with trypsin replacement nutritional therapy.

Patient concerns and diagnosis: After PD with trypsin replacement nutritional therapy, the patient developed acute steatorrhea.

Intervention: Individualized pharmaceutical care was provided by clinical pharmacists to address intolerance to pancreatin enteric-coated capsules following PD.

Outcomes: The clinical pharmacist's integration into the patient's treatment plan enhanced pharmacotherapy optimization, especially through pharmacokinetic monitoring and interventions related to nutritional therapy.

Lesson: Pharmaceutical care by clinical pharmacists aids in ensuring the safety and efficacy of drugs and nutritional treatment. Clinical pharmacists should be members of the nutrition support team.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Pancreaticoduodenectomy
  • Pancreatin
  • Pharmaceutical Services*
  • Pharmacists
  • Steatorrhea*
  • Trypsin

Substances

  • Pancreatin
  • Trypsin